Ubiquitin Connects with Planar Cell Polarity
نویسنده
چکیده
Planar cell polarity (PCP) regulates the orientation of cells in epithelia and of mesenchymal cells during gastrulation. In this issue, Narimatsu et al. (2009) report that the Smurf E3 ubiquitin ligases are required for localized protein degradation of a core PCP factor to generate cellular asymmetry.
منابع مشابه
Regulation of Planar Cell Polarity by Smurf Ubiquitin Ligases
Planar cell polarity (PCP) is critical for morphogenesis in metazoans. PCP in vertebrates regulates stereocilia alignment in neurosensory cells of the cochlea and closure of the neural tube through convergence and extension movements (CE). Noncanonical Wnt morphogens regulate PCP and CE in vertebrates, but the molecular mechanisms remain unclear. Smurfs are ubiquitin ligases that regulate signa...
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ورودعنوان ژورنال:
- Cell
دوره 137 شماره
صفحات -
تاریخ انتشار 2009